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pentobarbital will reduce the extent or effect of buprenorphine buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Contraindicated (1)pentobarbital will lower the extent or effect of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is accountable for the developme